# Cataracts
Category: Conditions
Also known as: cataract, lens opacity
Cataracts are a focal, opaque state of the lens caused by a disorganization of water within the lens cells, rather than by denaturation of the proteins themselves. Peat argued that the cataractous tissue is chemically almost identical to healthy surrounding tissue, but contains…
12 passages · 1 author · 2006–2021 · Most-cited: [Ray Peat](https://bioenergeticoracle.com/md/voices/ray-peat/index.md)
Canonical page: https://bioenergeticoracle.com/concepts/cataracts
## Synthesis
**Cataracts** are a focal, opaque state of the lens caused by a *disorganization of water* within the lens cells, rather than by denaturation of the proteins themselves. [Source 1, 2] Peat argued that the cataractous tissue is chemically almost identical to healthy surrounding tissue, but contains a slightly higher water content where the water has accumulated in a loose, uncontrolled form. [Source 1] This process is analogous to the way cooking makes an egg white opaque; the protein-water interaction is disrupted, destroying transparency. [Source 8] Peat distinguished a true cataract, which is a focal white opacity, from the normal **yellowing and browning of the lens** that occurs with aging, which can remain perfectly clear. [Source 4, 11]
The fundamental mechanism driving this opacity is a **loss of cellular energy** leading to a failure to maintain the organized, coherent state of water. [Source 1, 5] Peat explained that the lens, though lacking a blood supply, has its own circulatory system driven by oxidative metabolism in its surface epithelial cells, creating electrical and osmotic gradients that move fluid through the lens. [Source 6, 9] When energy production fails, the cells swell and take up excess water, losing their transparency. [Source 5, 9] This is consistent with Peat's view of the lens as a model of age-related inflammatory diseases, where a localized reversal of the general trend toward dryness occurs, and tissue takes up too much *unbound water*. [Source 8] The stressed cells also take up large amounts of calcium and sodium, while potassium and ATP decrease, and proteolytic enzymes are activated. [Source 9]
Peat identified several specific promoters and protective factors for this energetic failure. **Carbon dioxide** is a central protective molecule, and its deficiency, along with an increase in lactic acid, is typically found in cataracts. [Source 5] This explains why high altitude, which increases carbon dioxide retention, is strongly protective against cataracts, decreasing incidence by 2.7 times in one study, even despite increased ultraviolet radiation. [Source 5, 7] Conversely, stressors that damage the cell's energy state promote cataracts, including ionizing radiation, ultraviolet light, excessive estrogen, and endotoxin from the intestine. [Source 1, 4, 7] Peat also noted that **free fatty acids** are toxic to the lens, and that a surge of free fatty acids from stress can block glucose utilization, directly antagonizing the lens's energy supply. [Source 7, 10] Excessive cortisol or hypoglycemia can quickly produce cataracts, demonstrating the basic importance of **glucose metabolism** for lens health. [Source 9]
The condition is potentially reversible if the systemic environment is corrected. Peat cited the example of his brother, whose diagnosed cataract was later found to have disappeared, and noted that in vitro, a slightly hypertonic solution can cause an opacity to regress by drawing out excess water. [Source 4, 10] While a hypertonic saline solution can immediately clear a waterlogged cornea, it cannot reach the lens directly; the whole body's fluid balance must be shifted to restrain water accumulation in the lens. [Source 10] Peat highlighted the suppression of curative research due to the immense profitability of lens replacement surgery, but pointed to the steroid **lanosterol**, a cholesterol precursor found in mushrooms, which was shown in a major publication to reverse established cataracts in rabbits and dogs when applied as eye drops or injected. [Source 3, 12] Other protective substances he mentioned include aspirin, progesterone, caffeine, and red light, which reactivates cytochrome oxidase to increase ATP production. [Source 7]
## People also ask
### What causes the lens to become opaque in a cataract?
Peat argued that cataracts result from a disorganization of water within lens cells due to a loss of cellular energy, causing the cells to swell with excess unbound water rather than from protein denaturation.
### Why is carbon dioxide considered protective against cataracts?
The entry states that carbon dioxide is a central protective molecule, and its deficiency, along with increased lactic acid, is typically found in cataracts; high altitude, which increases CO2 retention, strongly decreases cataract incidence.
### Can an established cataract be reversed without surgery?
Peat noted that cataracts are potentially reversible by correcting the systemic environment, citing the disappearance of a diagnosed cataract and research showing the steroid lanosterol reversed cataracts in animals when applied as eye drops.
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## Cited passages
Passage numbers match the `[Source N]` markers in the synthesis above.
### Source 1 — Ionizing Radiation in Context 2 — Politics & Science, 2009
Ray Peat · Interview · 2009
> **Ray Peat:** Cataracts are another interesting thing. They're easy to study in a way, because the cataract is a different state of the living matter. And people have been trained to understand what happens in a cataract. And it's probably analogous to what happens in Alzheimer's disease; it’s a much simpler system made up of very few types of proteins. And it turns out that in the cataract, the proteins aren't even denatured. To make a cataract develop, you would think that the radiation would have to at least change the proteins. Surgeons get cataracts from exposure to x-rays; people who work around any kind of even low level radiation microwaves, and so on, get cataracts. And it turns out that the cataract is chemically almost identical to the surrounding tissue; but it's wetter, [containing a] slightly higher water content than the healthy tissue around it. And all that happens is a slight fluctuation in the electronic state of the protein; and that lets the water get out of control; it accumulates, rather than being under the influence of the systems of proteins, and the electronic fields of these proteins. It lets you see in a very concrete way how energy makes all the difference between the lens that works and the lens that's opaque. It’s not thermal energy in the ordinary sense; but it would classify as thermal energy because it's just the vibrational state of the water molecules which has changed. And similar changes probably happen very early in a disease like Alzheimer's or cancer, [where] if the tissue was visible, you would probably see it as a changing state of the water and [of the] electronic behavior of the proteins, analogous to the opacity of the lens, long before you got any of the major deposition of amyloid and plaque formation that eventually shows up in the tumors, or the Alzheimer's brain, and so on.
### Source 2 — Voice of America: Misconceptions about Nutrition - Sharon Kleyne + Ray Peat
Ray Peat · Interview · 2013 · http://l-i-g-h-t.com/files/voice-of-america-water.mp4
> **Sharon Kleyne:** I also want to ask you about aging eyes, infant eyes and your research. Tell us about what you were learning about eyes.
>
> **Ray Peat:** I especially got interested in how the transparency of the cornea lens and vitreous humor, how that works, when I was in Mexico at Lake Patzcuaro. The fish there were transparent, at least they used to be, I think pollution is changing it. In the market they would pile up fish that were the size of small trouts and even some 8 inches long, others about the size of a cigar - where you could read a magazine cover right through the fish. Absolute transparency. That got me interested in the issue of what makes the sclera or the cornea or the lens able to be transparent even though it has relatively little water. Itʼs a very tough, hard rubbery tissue. And the state of the water is so organized and you have to think about Gerald Pollackʼs research to think about what organization can mean to water, the molecules are lined up such that the quantum energy is organized as it moves through. Theres another very important website - Mae- Wan Ho - called ʻISISʼ The Institute of Science in Society. She writes about the coherence of organisms involving this quantum level organization of water molecules and she has illustrations of the color continuity right through a whole organism showing that the light has to be organized by the organism as a whole, not by individual random atoms. In the lens and the cornea, what this means that, if for example, you have too much inflammation, estrogen, ultraviolet radiation, anything that excites the tissue too much, it lets the water get disorganized. And the water content increases, just the way edema causes water to accumulate in your feet or fingers where it shouldnʼt be. The water accumulates in loose form and thatʼs what causes the opacity of a cataract. Itʼs actually too much water because itʼs out of control and disorganized.
### Source 3 — Cataracts
Ray Peat · Newsletter · 2014
> Until the 1970s, the literature was dominated by the view that the lens was a lifeless material, like hair and toenails, and even in 2013 there is great reluctance of researchers to recognize its vital cellular activity.
>
> After an artificial lens has been implanted, there are great changes in the vitreous humor (which fills the space between the retina and the lens), with a reversal of the gradient of viscosity, and with changes in many proteins, including transthyretin, alpha antitrypsin, retinoic acid binding protein, antioxidant proteins, and the enzymes carbonic anhydrase and triosephosphate isomererase.[[36](#ref036)]
>
> I haven't seen any recent studies of the effects of lens removal on the nervous system, but a 1953 study of 21 patients reported a high percentage of behavioral disturbances following the surgery: “Following the operation 20 patients showed some alteration in behavior including changes in mood, psychomotor disturbances, paranoid and somatic delusions, hallucinations, disorientation and confabulations. In 3 cases the disturbance was characterized as severe.” “It is concluded that disturbed behavior is an integral part of the reaction of almost all cataract patients because of a complex interaction of a number of factors”.[[27](#ref027)]
>
> In animal studies, when the lens capsule is closed after removal of the lens, within a few weeks a well formed lens has regenerated;[[19](#ref019)] cell division is stimulated in the cells remaining attached to the capsule, similar to the regeneration of the adrenal cortex after its removal.
>
> Artificial replacement lenses are designed (with an ultrasharp edge) to block the regenerative migration of cells within the capsule, because the cells can quickly form a new cataract behind the plastic lens; those cataracts commonly form in reaction to the lens. The use of arsenic to kill these cells has been proposed, and probably used.[[53](#ref053)]
>
> The easy money in lens surgery has obviously discouraged professional interest in preventing cataracts, or curing them, or stimulating the regeneration of new lenses. Research in the prevention of cataracts has encountered serious barriers to performing the clinical trials that would be necessary for approval.
### Source 4 — One Radio Network: Ray Peat with Patrick Timpone — December 21, 2020
Ray Peat · Interview · Dec 21, 2020
> **Ray Peat:** By putting an animal lens with a cataract into a culture dish, they have found that it's responsive to the osmolarity of the solution, that a watery solution expands a cataract and a slightly over-concentrated solution solution can regress a cataract. And inflammation generally creates a watery, low osmolarity solution that contributes. The cataract itself becomes opaque because the cells take up more water than normal. And in that process, they are losing not only their transparency, but their resilience. The proteins in the cell are like egg white. When it's cooked, it's opaque and firm. When it's functional and alive and clear, the water is in a special state. And things that Damage the cell's ultraviolet light or too much estrogen, for example, are things that will change the state of water in the cell, make it over-hydrated, hardened, and opaque. And so keeping systemic inflammation low, avoiding the things that tend to waterlog your tissues, all of those reduce the progress of cataracts. And incidentally, lots and lots of optometrists are now exaggerating the language they're telling people they have developing cataracts when what they're really seeing is just a normal yellowing and browning of the lens with aging. An old yellowed or browned lens can still be very clear. It's not a cataract. It's just the change of color with aging. A cataract is a more or less focal spot where the cells turn white and become opaque as the take up too much water in the wrong arrangement
### Source 5 — The Transparency of Life
Ray Peat · Newsletter · 2006
> The Bohr-Haldane effect describes the fact that hemoglobin releases oxygen in the presence of carbon dioxide, and releases carbon dioxide in the presence of oxygen. When oxygen is too abundant, it makes breathing more difficult, and one of its effects is to cause carbon dioxide to be lost rapidly. At high altitude, more carbon dioxide is retained, and this makes cellular respiration more efficient.
>
> The importance of carbon dioxide to cell control process, and to the structure of the cell and the structure of proteins in general suggested that degenerative diseases would be less common at high altitude. Wounds and broken bones heal faster at high altitude, but the available statistics are especially impressive in two of the major degenerative conditions, cancer and cataracts.
>
> The two biggest studies of altitude and cataracts (involving 12,217 patients in one study, and 30,565 lifelong residents in a national survey in Nepal) showed a negative correlation between altitude and the incidence of cataract. At high altitude, cataracts appeared at a later age. In Nepal, an increase of a few thousand feet in elevation decreased the incidence of cataracts by 2.7 times. At the same time, it was found that exposure to sunlight increased the incidence of cataracts, and since the intensity of ultraviolet radiation is increased with altitude, this makes the decreased incidence of cataracts even more important.
>
> All of the typical causes of cataracts, aging, poisons, and radiation, decrease the formation of carbon dioxide, and tend to increase the formation of lactic acid. Lactic acid excess is typically found in eyes with cataracts.
>
> The electrical charge on the structural proteins will tend to increase in the presence of lactic acid or the deficiency of carbon dioxide, and the increase of charge will tend to increase the absorption of water.
>
> The lens can survive for a considerable length of time *in vitro* (since it has its own circulatory system), so it has been possible to demonstrate that changes in the composition of the fluid can cause opacities to form, or to disappear.
>
> Oxidants, including hydrogen peroxide which occurs naturally in the aqueous humor, can cause opacities to form quickly, but they will also disappear quickly in a solution that restores metabolic energy. The lens regulates itself powerfully; for example, it will swell when put into a hypotonic solution, but will quickly adapt, returning to approximately its normal size.
### Source 6 — The Transparency of Life
Ray Peat · Newsletter · 2006
> The lens of the eye is a fairly dense, tough, transparent living structure, which can develop opaque areas, cataracts, as a result of old age, poisoning, radiation, disease, or trauma. The varieties of cataract relate to the causes. Most of the oxidative metabolism of the lens is in or near the epithelial layer that surrounds it. Old-age cataracts most often begin in this region.
>
> Although the efficient oxidative energy metabolism occurs near the surface of the lens, there is a constant flow of fluid through the lens, entering it mainly in the front and back, and leaving on its “sides” or equator (considering the front and back as the poles, the direction light passes through). Oxygen and nutrients are supplied to the lens by way of this circulation of fluid, entering mostly from the aqueous humor in front (which also supplies the cornea), but also from the vitreous humor behind the lens.
>
> When the flow of nutrients and energy is impaired, the organized state of the protein and water system in the cell is damaged, and an excess of water is taken up by the cells, as the protein content decreases. The loss of organization causes light to be dispersed, with a loss of transparency.
>
> The lens of the eye is usually treated as something so specialized that it is hardly considered to be part of our living substance, just as dentistry has tended to treat teeth as inert things to be approached mechanically, rather than physiologically. The lens's circulatory system is very interesting, because of what it says about the nature of living substance. In the absence of blood vessels, it provides its own flow of nutrients. This flow is reminiscent of the flow of substances through the dentine channels of the teeth, through the axons of nerves (two-way transport in a very narrow channel), and, in some ways recalls the flow of fluids in plants, called “guttation” (drop formation), which is disturbing to botanists, because it is contrary to the textbook descriptions of proper physiology.
>
> The flow of material through lens cells, dentine canals, and nerve axons should allow us to gain a perspective in which these observable processes become a model for other biological situations in which “transport” occurs: Kidney, intestine, or the skin of frogs, for example, in which water, ions, and other solutes are moved in considerable quantities.
>
> When cells metabolize, they create gradients.
### Source 7 — Cataracts
Ray Peat · Newsletter · 2014
> Free fatty acids are toxic to the lens, which contains the enzymes for synthesizing prostaglandins and related promoters of inflammation; the products of lipid peroxidation are increased in people with cataracts. Endotoxin from the intestine increases the formation of nitric oxide, so it's essential to minimize intestinal inflammation.
>
> High altitude very strongly protects against cataracts.[[8](#ref008)] Low oxygen tension itself protects the lens's clarity,[[3](#ref003)] possibly by the protective effect of increased carbon dioxide against glycation of protein amino groups. Aspirin's known anticataract effect apparently involves a similar protection of crystallin against glycation, but aspirin has several other protective effects, including prevention of protein cross-linking, and the inhibition of the synthesis of nitric oxide and prostaglandins and other disruptive materials.[[13](#ref013), [6](#ref006), [28](#ref028)] Progesterone's inhibition of nitric oxide production is probably protective for the lens, paralleling its effects in other organs. Inhibitors of nitric oxide, such as aminoguanidine, are protective. Anticholinergics, including atropine, inhibit over-hydration of the lens and prevent cataracts caused by excessive cholinergic stimulation.[[24](#ref024)] Caffeine, in animal experiments, prevents cataracts. Uric acid, which inhibits nitric oxide formation, is reduced in people with cataracts. The factors that prevent or promote other degenerative diseases are similarly protective or harmful for the lens.
>
> [references]
### Source 8 — The Transparency of Life
Ray Peat · Newsletter · 2006
> # The Transparency of Life
>
> In the markets around Lake Patzcuaro, they sell green transparent fish, about 6 inches long. When cooked, the meat is white, like ordinary fish. Most fish filets are a little translucent, but are at least cloudy, and usually pink by transmitted light. I don't know how the transparent fish work, because it seems that the blood and the network of blood vessels needed to sustain muscle activity would diffuse the light. Anyway, cooking disrupts the mysteriously ordered state of water and proteins that makes them transparent, roughly the way egg-white loses its transparency when it is cooked. I have never heard a convincing explanation for the opacity of cooked egg-white, either, but anything that disrupts the original structuring of the protein-water interaction will destroy the transparency.
>
> Around 1970, I used a technique called nuclear magnetic resonance (NMR), which is the basis for the procedure known as MRI (magnetic resonance imaging), to compare the state of water in old (uterine) tissue and young tissue. Old tissue predictably contains less water than young tissue, but I found that the water in the old tissue was in a relatively free and uncontrolled state. When tissue swells and takes up water, more of the water is likely to be in this uncontrolled state, and this is one of the things that makes MRI so useful, because tumors, for example, show up vividly because of their large amount of uncontrolled (“unbound”) water. I suspect that the measurements I made on uterine tissue showed a localized effect, that opposed the general trend toward increased dryness with aging. In the case of cataracts, this is clearly the case: Most of the lens becomes drier with age, but at a certain point there is a reversal, and some of the tissue takes up too much water. That's why I refer to cataracts as a model of age-related disease, rather than as a model of aging. In this sense, I am including them among the inflammatory diseases of aging—colitis, arthritis, and cancer, for example. MRI now can show developing cataracts before they are visible, because of increased water content in the area.
>
> The lens of the eye is a fairly dense, tough, transparent living structure, which can develop opaque areas, cataracts, as a result of old age, poisoning, radiation, disease, or trauma.
### Source 9 — Cataracts
Ray Peat · Newsletter · 2014
> Similarly, cataracts have been described as more rigid than normal lens tissue,[[21](#ref021), [22](#ref022)] yet their water content is higher.[[40](#ref040)] Along with the increased water, the stressed cells take up very large amounts of calcium, and sodium increases while potassium decreases. Inorganic phosphate increases in the stressed cells, some of it entering with the circulating fluid, but some of it produced from the ATP which is decreasing. Serotonin, iron, lipid peroxidation products, nitric oxide, and prostaglandin are also increased. The increased calcium activates proteolytic enzymes that break down protein.
>
> In the failing heart and growing tumors, there is an increase in the quantity and the cross-linking of collagen in the extracellular matrix, contributing to the overall hardness, besides the contracted state of the cells themselves. In the cataract, cross-linking of various proteins, including collagen, also seems to be involved in the problem, along with the altered state of the water.[[32](#ref032), [16](#ref016)] The cross-linking enzyme transglutaminase is induced by stressors such as ultraviolet light which produce cataracts.
>
> When the available energy doesn't meet the cell's energy requirements, if the cell isn't quickly killed by the stress it will use some adaptive mechanisms, stopping some repair processes to reduce energy expenditure, possibly stopping specialized functions to reduce energy needs. Fibrotic changes occur as a result of defensive reactions in stressed cells, usually following long periods of fatigue and inflammation. Cortisol generally protects cells by blocking over-stimulation and providing increased material for energy and repair, but it can kill cells (nerve cells and thymus cells) that depend on glucose oxidation, leading to immunodeficiency and excitotoxic brain damage. The glucose-dependent lens fiber cells express the same glucose transporters, GLUT 1 and GLUT 3, as the brain, and the “nerve specific” GLUT 3 is concentrated in the dense nucleus of the lens.[[15](#ref015)] Exposure to excessive cortisol or hypoglycemia is able to quickly produce cataracts, showing the basic importance of glucose metabolism for lens health.
### Source 10 — Dr. Ray Peat, Ph.D - Your Health Questions Answered - March 2, 2021 | One Radio Network
Ray Peat · Interview · 2021
> **Patrick Timpone:** So regular use of olive oil in your opinion is fine.
>
> **Ray Peat:** Well butter is better because it’s only about three percent of the bad stuff but if you hold your olive down to flavoring, maybe a teaspoon or so. It gives good flavor at that amount with out much danger. But butter is like three times as safe.
>
> **Patrick Timpone:** Hm, butter is the safest. Isn’t that interesting. Okay here’s an email fast developing cataract on my right eye and I’ve been reluctant to have a surgery due to sojourns. Any available therapies or remedies for this?
>
> **Ray Peat:** O, people my brother for example had a cataract diagnosed when he was about 70 and in his late 70s he went back and the oculist said he could see where there had been one but there was no trace of a functioning cataract left. So people do recover from them when their physiology changes but the lack of...the loss of energy to those cells that become opaque leads to them swelling just like any deenergized tissue swells; takes up water and the water, the effect is like cooking egg-white. The change of the water form an organized transparent state, it becomes an opaque like a cooked egg white and in the cornea of the eye that can happen to. A women with for some reason extreme water retention. I knew some one who in just a period of a few hours went blind in both eyes because the corneas became white and opaque. And bathing her eyes in a slightly hyper-tonic salt solution, the hyper-tonic salt solution removed some of the excess water and immediate her eyes were clear again. Anything that can shift your balance away from that water disorganization and retention effect can let the cataract clear up.
### Source 11 — One Radio Network: Ray Peat with Patrick Timpone — December 21, 2020
Ray Peat · Interview · Dec 21, 2020
> And incidentally, lots and lots of optometrists are now exaggerating the language they're telling people they have developing cataracts when what they're really seeing is just a normal yellowing and browning of the lens with aging. An old yellowed or browned lens can still be very clear. It's not a cataract. It's just the change of color with aging. A cataract is a more or less focal spot where the cells turn white and become opaque as they take up too much water in the wrong arrangement. Interesting. Linda's in Michigan. Dear Patrick, I looked for you on MeWe, couldn't find you. Just do Patrick Timpone on MeWe and you'll find us. Could you please ask Dr. Pete if he would think what could a pillow... that's infused with silver, could that be a beneficial effect on protecting from EMFs? Wow. Doing what with silver? Or a silver-infused pillow? Oh, no, I think the conductor has to be between you and the source of the EMF, so you can get curtains with embedded wire filaments, silver or copper or whatever, and if you have a telephone tower visible through your window, and you put a big drape over the window, and maybe over any of the wall between you and the tower, that is protective. David is in Atlanta, Georgia, listening this morning, or watching, whatever. Dr. Pete, you've said that metabolism and epigenetic damage causes baldness. My metabolism has improved, but I'm still bald, so how can I undo the epigenetic damage and grow some hair? The tissue, once it's damaged, has changed its structure and laid down a lot of collagen and fiber cells, and so the examples of people who have gone from complete baldness to regrowing a good crop of hair, it has usually involved some kind of shock. To the tissue that activates repair processes that will actively clean out some of the fibrous tissue, probably massage would be the best bet to activate the fibrous tissue, but the cells are doing like putting a niacin or something that simply causes a local inflammation. Not niacinamide, but the the one that makes the skin turn red. That sort of thing creating a mild inflammation.
### Source 12 — Steiner Schools and Education KMUD 2015
Ray Peat · Interview · 2015
> **Sarah Johannesen Murray:** You would have to eat a lot of them to get a really large dose of omega oils.
>
> **Andrew Murray:** Do you use chia seeds because you have issues with constipation ? Cascara helps a lot for bowel movements.
>
> **Caller:** Yes; the chia seeds helped a lot with my constipation.
>
> **Ray Peat:** I just didn’t have any experience with them myself. But i know psyllium seeds work for many people.
>
> **Caller:** I think i tried them before, and got intestinal cramps.
>
> **Sarah Johannesen Murray:** Then you’re obviously had an allergic reaction to the psyllium.
>
> **Andrew Murray:** Dr Peat, i wanted to ask you about the latest scientific findings about a product called lanosterol, used to treat cataracts without surgery. It’s extremely inexpensive and it works.
>
> **Ray Peat:** I was just a little surprised to see a big publication in Nature. And this group, at the University of California, San Diego, was actually reversing the majority in something like a dozen rabbits, and then dogs. Both using eye-drops and injecting it directly into the eyeball. They actually got established cataracts to clear up. And when i wrote a newsletter about cataracts, a couple of years ago, i noticed that research in treating and curing cataracts had been suppressed because of the immense amount of money there is in removing the lens during cataract surgery; it’s a multi-million dollars business. And that money interest had just wiped out practically all curative research in eye studies.
_Generated 2026-07-20 from the Bioenergetic Oracle corpus._