Dopamine

Dopamine (DA) is a neurotransmitter involved in various physiological processes, including mood regulation, motivation, and reward processing. According to Ray Peat, low thyroid function is often associated with high adrenaline levels, which can be measured by taking temperature and pulse rate before and after eating 1. A normal pulse rate in the middle of the day is around 80-85 beats per minute, and a temperature of 98 degrees Fahrenheit 1.

Estrogen has been shown to influence dopamine levels, with 17 beta-estradiol increasing the metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum, while not changing dopamine concentrations 2. This suggests that estrogen may modulate dopamine activity through its effects on dopamine receptors.

Dopamine agonists, such as lisuride, have been found to stimulate dopamine autoreceptors, leading to premature ejaculation in rats 4. However, Georgi Dinkov notes that dopamine agonists can induce epigenetic changes and cause long-lasting or permanent fatigue, anxiety, and lack of motivation in some users 6.

Research has also suggested that vitamin D deficiency may be linked to low dopamine levels, which can contribute to schizophrenia 7. Additionally, Georgi Dinkov has written that high serotonin levels, rather than low dopamine levels, may be the main driver of Parkinson's disease 8.