Skip to main content

Concept encyclopediaTheories & Frameworks

Hydrophobic

Insoluble in water, a nonpolar oil-like molecule that repels water.

4 passages
2 authors
2013–2020
Most-cited: Ray Peat

Hydrophobic refers to a nonpolar oil-like molecule that repels water, making it insoluble in water . This characteristic is relevant in various biological processes, including cellular respiration, where hydrophobic molecules play a crucial role in energy production.

In cellular respiration, oxidation of fuel in the mitochondrion is coupled to the phosphorylation of ADP, forming ATP, a process known as coupling . However, certain chemicals, such as uncouplers like DNP, can disrupt this process, allowing oxidation to proceed without producing the usual amount of ATP, a phenomenon known as uncoupling . This process is relevant in understanding fatigue and aging, as the cellular processes involved in fatigue overlap with those of aging .

The concept of hydrophobicity is also relevant in the context of androgenic compounds, such as androsterone, which can be dissolved in hydrophobic vaseline and ethanol for topical application . However, the safety of combining such compounds with other substances, such as DMSO and ethanol, is not explicitly addressed in the provided sources.

People also ask

Related concepts