Oxidation

Oxidation refers to the combination of a substance with oxygen, which can be beneficial, as in normal respiration that produces energy, or harmful, as in rancidity, irradiation, or stress reactions 1.

The process of oxidation is closely related to the functioning of mitochondria, the structures inside cells where energy is produced through respiration. The vitality of mitochondria is influenced by nutrition and hormones, and their capacity for oxidative energy production is essential for life 2.

Oxidative metabolism is a highly efficient way of producing energy, where oxygen is used by mitochondria to produce ATP and carbon dioxide. This process is crucial for the proper functioning of tissues and organs, and is promoted by thyroid hormone 3.

In the context of cellular metabolism, oxidation is a key process that involves the transfer of electrons, which can be either reduced or oxidized. A redox balance in favor of reduction is essential for life, and is characterized by the addition of electrons to molecules, increasing their energy 5.

The oxidation of fatty acids is a critical process that produces malonyl COA, which specifically inhibits the propra dehydrogenase complex. This process is essential for the proper functioning of the TCA cycle and the production of energy 6.

Interestingly, research has shown that diabetic rats have the same rate of glucose oxidation as normal rats, suggesting that the oxidation of glucose is not impaired in diabetes 8. However, the oxidation of fatty acids is increased in diabetes, which can lead to a range of complications.

It's worth noting that the concept of oxidation has evolved over time, and different researchers have approached it from different angles. For example, Ray Peat has emphasized the importance of thyroid hormone in promoting oxidative metabolism, while Danny Roddy has discussed the role of mitochondria in energy production and the importance of reducing entropy 3.